Ontology-based Brucella vaccine literature indexing and systematic analysis of gene-vaccine association network
نویسندگان
چکیده
منابع مشابه
Literature Mining and Ontology based Analysis of Host-Brucella Gene–Gene Interaction Network
Brucella is an intracellular bacterium that causes chronic brucellosis in humans and various mammals. The identification of host-Brucella interaction is crucial to understand host immunity against Brucella infection and Brucella pathogenesis against host immune responses. Most of the information about the inter-species interactions between host and Brucella genes is only available in the text o...
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BACKGROUND Ontologies are useful in many branches of biomedical research. For instance, in the vaccine domain, the community-based Vaccine Ontology (VO) has been widely used to promote vaccine data standardization, integration, and computer-assisted reasoning. However, a major challenge in the VO has been to construct ontologies of vaccine functions, given incomplete vaccine knowledge and incon...
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Brucellosis is caused by the bacterium Brucella and affects various domestic and wild species. GroEL (Heat Shock Protein 60kDa) as one of the major antigens that stimulate the immune system, increases Brucella survival. The aim of the current study was to clone and express GroEL in Escherichia coli in order to design subunit vaccine. Amplifying was performed using specific primers. The full-len...
متن کاملIdentification of fever and vaccine-associated gene interaction networks using ontology-based literature mining
BACKGROUND Fever is one of the most common adverse events of vaccines. The detailed mechanisms of fever and vaccine-associated gene interaction networks are not fully understood. In the present study, we employed a genome-wide, Centrality and Ontology-based Network Discovery using Literature data (CONDL) approach to analyse the genes and gene interaction networks associated with fever or vaccin...
متن کاملDevelopment and application of an interaction network ontology for literature mining of vaccine-associated gene-gene interactions
BACKGROUND Literature mining of gene-gene interactions has been enhanced by ontology-based name classifications. However, in biomedical literature mining, interaction keywords have not been carefully studied and used beyond a collection of keywords. METHODS In this study, we report the development of a new Interaction Network Ontology (INO) that classifies >800 interaction keywords and incorp...
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ژورنال
عنوان ژورنال: BMC Immunology
سال: 2011
ISSN: 1471-2172
DOI: 10.1186/1471-2172-12-49